Overview

Found Parkinsons SNPs
Not Our Families Parkinsons SNP

Sheet 1: Found Parkinsons SNPs
List of Parkinson's Disease Related Snp's, The Gene effected, and Our Families Situation Therein
Gene SNP Chromozone Position Known Bad Allele Richard Norma Notes
interg rs6963573 7 36794925 A GG GG rs6963573 is in linkage disequilibrium with a polymorphism that increases susceptibility to Parkinson's disease 1.71 times for carriers of the A allele
interg rs10918270 1 160182125 GG AG Genomewide Association Study for Onset Age in Parkinson Disease A allele
interg rs11737074 4 125300823 A GG GG increases susceptibility to Parkinson's disease 1.50 times for carriers of the A allele
interg rs6532194 4 90999925 CC CC
SLC2A13 rs10877840 12 38639263 CT CT
? rs1509269 4 138973174 C CT CT increases susceptibility to Parkinson's disease 1.71 times for carriers of the C allele
? rs6847679 4 138982076 C CT CT rs6847679 is in linkage disequilibrium with a polymorphism that increases susceptibility to Parkinson's disease 1.71 times for carriers of the C allele
ACMSD rs6710823
135308851 G*

not in our family
ADH1C rs283413
100487213 T*

not in our family
ADORA2A rs5751876 22 23167301 CC CC adenosine A2a receptor
ATP11B rs11711441
184303969 G*

not in our family
BCS1L rs28937590 2 219234186 AA AA BCS1-like (S. cerevisiae)
BMP4 rs12431733 14 53360580 T CT CC bone morphogenetic protein 4
BST1 rs4538475 4 15347035 G AA AA bone marrow stromal cell antigen 1
BST1 rs4698412 4 15346446 A AG GG bone marrow stromal cell antigen 1
BST1 rs11724635 4 15346199 A*

not in our family
C20orf82 rs1223271 20 13244912 G AG AG
CALB1 rs1805874 8 91151238 CC CC calbindin 1, 28kDa
CAST rs1559085 5 96104458 AG AA calpastatin
CCDC62 rs12817488
121862247 T*

not in our family
CTSB rs1296028 8 11736156 AA AA cathepsin B
CYP17A1 rs17115100 10 104581383 G GG GG cytochrome P450, family 17, subfamily A, polypeptide 1
CYP2D6 rs3892097
40854891 A*

not in our family
DBC1 rs4837628 9 121099530 A CT CC deleted in bladder cancer 1
DGUOK rs11248060 4 954359 CT CC deoxyguanosine kinase
DK rs1536076
17721921

not in our family
DK rs1765841
29842676

not in our family
DLG2 rs10501570 11 84095494 TT TT discs, large homolog 2 (Drosophila)
EXON 1 rs2313982 4 139007510 T AG AG
FGF20 rs1721082 8 16894503 T TT AT fibroblast growth factor 20
FGF20 rs1721100 8 16894869 C GG CG fibroblast growth factor 20
GAK rs11248051 4 848332 T CT CC cyclin G associated kinase e risk of developing the condition in some families
GAK rs1564282 4 842313 T CT CC cyclin G associated kinase e risk of developing the condition in some families
GAK rs6599389 4 929113 A AG AG cyclin G associated kinase
GAK rs6599388 4 929087 T

not in our family
GALNT3 rs16851009 2 166338953 T CC CT UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
GBA i4000416
153472258 C

not in our family
GNA13 rs6692804 1 109910265 A GG GG guanine nucleotide binding protein (G protein), alpha 13
GWA_10q21.1 rs35866326 10 58986929 C CC CC rs35866326 increases susceptibility to Parkinson's disease 1.88 times for carriers of the C allele
GWA_5p15.32 rs7723605 5 5407615 TT TT
HLA-DRA rs3129882 6 32517508 G AA AA The association peak we found was at rs3129882 a noncoding variant in HLA-DRA.
HMCN2 rs1006615 9 132298601 CT CT rs1006615 is associated with increased risk for schizophrenia in German and Scandinavian samples
interg rs17329669 7 36818454 G AA AA increases susceptibility to Parkinson's disease 1.71 times for carriers of the G allele
interg rs6430538 2 135256437 CC CC
interg rs1480597 10 44481115 CC CT
Interg rs2395163 6 32495787 TT TT
interg rs4964469
105474117 A

not in our family
ITGA8 rs7077361 10 15601549 T TT TT integrin, alpha
L444P rs35095257
53951566


not in our family
LINGO1 rs9652490 15 75750942 AA AG AA 2x increased risk for Parkinson's disease,
LRRK2 rs1994090 12 38714828 GT GT leucine-rich repeat kinase 2
LRRK2 rs33949390 12 39000112 C GG GG leucine-rich repeat kinase 2
LRRK2 rs34637584 12 39020469 A GG GG leucine-rich repeat kinase 2
LRRK2 rs34778348 12 39043595 A GG GG leucine-rich repeat kinase 2
LRRK2 rs1491942 12 38907075 G

not in our family
MAGI1 rs2275336 6 154768680 GG GG membrane associated guanylate kinase, WW and PDZ domain containing 1
MAOB rs1799836 X 43512943 T T CT monoamine oxidase B
MAPT rs12185268 17 41279463 A AG AG microtubule-associated protein tau
MAPT rs1800547 17 41407682 G AG AG microtubule-associated protein tau
MAPT rs199533 17 42184098 C AG AG microtubule-associated protein tau
MAPT rs393152 17 41074926 A AG AG microtubule-associated protein tau
MAPT rs6438552 17 121114504 AG AG microtubule-associated protein tau
MAPT rs8070723 17 41436901 AG AG microtubule-associated protein tau
MAPT rs199515 17 42211804


not in our family
MAPT rs2942168 17 41070633 G

not in our family
MCCC1 rs10513789 3 184242767 T TT TT methylcrotonoyl-CoA carboxylase 1 (alpha)
MMRN1 rs6532197 4 91016324 G AA AA multimerin 1
NDUFV2 rs906807 18 9107867 CC CC NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa
NELL1 rs11026412
22070669


not in our family
NSF rs10464059 5 179726814 A AG AG N-ethylmaleimide-sensitive factor
NSF rs183211 17 42143493 T AG AG N-ethylmaleimide-sensitive factor
PARK10 rs2494876 1 50439102 TT TT Parkinson disease 10 (susceptibility)
PARK10 rs682705 1 54410005 AA AG Parkinson disease 10 (susceptibility)
PARK10 rs967582 1 50354759 AC AC Parkinson disease 16 (susceptibility)
PARK10 rs75200966 1 60935760

not in our family
PARK16 rs823128 1 203980001 A AA AA Parkinson disease 16 (susceptibility)
PARK16 rs947211 1 204019288 A AG AG Parkinson disease 10 (susceptibility)
PARK2 rs1801582 6 161727845 CC CC parkinson protein 2, E3 ubiquitin protein ligase (parkin)
PARK2 rs992037 6 161921426 T CC CC parkinson protein 2, E3 ubiquitin protein ligase (parkin)
PARK7 rs3766606 1 7944784 GG GG parkinson protein 7
PITX3 rs3758549 10 103994185 CC GG GG paired-like homeodomain 3
PLEKHM1 rs11012
40869224 T

not in our family
PRDM15 rs2839398
42159421


not in our family
PRDM2 rs2245218 1 14012413 G TT TT PR domain containing 2, with ZNF domain
PRDM2 rs2697962 1 14023579 A CC CC PR domain containing 2, with ZNF domain
PRKAG2 rs28938173 7 150896769
GG GG protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PRNP rs1799990 20 4628251 AA AA AA prion protein
PRSS53 rs11155313 6 144003270 G AA AG protease, serine, 53
PRSS53 rs11865038 16 31002672 CC CT protease, serine, 53
RAI1 rs2297508
17656042


not in our family
RIT2 rs12456492
38927378


not in our family
RORA rs10519131 15 59788424 AA AA RAR-related orphan receptor A
SCARB2 rs6812193 4 77418010 CC CT CT
SEMA5A rs6896702 5 9384848 T TT -- sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SEMA5A rs7702187 5 9385281 A AA AA sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SLC41A1 rs823156 1 204031263 A AG AG solute carrier family 41, member 1
SLC50A1 rs12726330
153374791


not in our family
SNCA rs7617877 4 28680768 A AG GG
SNCA rs11931074 4 90858538 GG GG synuclein, alpha (non A4 component of amyloid precursor)
SNCA rs2736990 4 90897564 C GG AG synuclein, alpha (non A4 component of amyloid precursor)
SNCA rs356219 4 90856624 G GG AG synuclein, alpha (non A4 component of amyloid precursor) a tagging SNP for a Parkinson's disease
SNCA rs356220 4 90860363 AT TT CT synuclein, alpha (non A4 component of amyloid precursor)
SREBF1 rs11868035 17 17655826 G GG GG sterol regulatory element binding transcription factor 1
SREBF1 rs11868035 17 17655826 GG GG sterol regulatory element binding transcription factor 1
STAP1 rs2242330 4 68129844 AA AG signal transducing adaptor family member 1
STK39 rs9917256 2 168851281
GG AG serine threonine kinase 39
STK39 rs2102808 2 168825271 C

not in our family
SYT11 rs34372695 1 154296661 T CC CC synaptotagmin XI
SYT4 rs4130047 18 38932233 C CT TT synaptotagmin IV
TAS1R2 rs12063142 1 19012104 CC CT taste receptor, type 1, member 1
TM4SF20 rs10200894 2 228525376 C CC CC increases susceptibility to Parkinson's disease 1.84 times for carriers of the C allele transmembrane 4 L six family member 20
UNC13B rs10121009 9 35259819 A CT CC unc-13 homolog B (C. elegans) candidate genes for PD in Ashkenazi Jewish populations
USP25 rs2823357 21 15836776 A GG GG ubiquitin specific peptidase 25
USP40 rs287235 1 55451087 CC CG CG ubiquitin specific peptidase 40 have been linked to Parkinson's disease
USP40 rs838552 2 234086768 A AA AA ubiquitin specific peptidase 40 have been linked to Parkinson's disease
WNT3 rs415430 17 42214305 T CT CT not in our family

Sheet 2: Not Our Families Parkinsons SNP
i4000416 C GBA 153472258
rs11012 T* PLEKHM1 40869224
rs11026412 * NELL1 22070669
rs11711441 G* ATP11B 184303969
rs11724635 A* BST1 15346199
rs12456492 ?* RIT2 38927378
rs12726330 ?* SLC50A1 153374791
rs12817488 T* CCDC62 121862247
rs1491942 G* LRRK2 38907075
rs1536076 ? DK 17721921
rs1765841 ? DK 29842676
rs199515 ?* MAPT 42211804
rs2102808 C* STK39 168825271
rs2297508 ?* RAI1 17656042
rs283413 T* ADH1C 100487213
rs2839398 ?* PRDM15 42159421
rs2942168 G* MAPT 41070633
rs35095257 * L444P 53951566 appears to increase the odds of developing Parkinson's disease by at least 5 fold,
rs3892097 A* CYP2D6 40854891 Parkinson's disease upon exposure to pesticides is increased from 3 to 8 fold among carriers of CYP2D6*
rs4964469 A* interg 105474117
rs6599388 T GAK 929087
rs6710823 G* ACMSD 135308851
rs75200966 ? PARK10 60935760